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KMID : 0043319900130010064
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Archives of Pharmacal Research
1990 Volume.13 No. 1 p.64 ~ p.68
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A Study of Stabilization Effect of alpha-Tocopherol Incorporated into Liposomal Phospholipid Membrane
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Bae SJ
Kim NH
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Abstract
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The stabilization effect of alpha-tocopherol incorporated into liposomal phospholipid membrane was investigated by fluorospectrophotometry and UV-visible spectrophotometry. The release of entrapped carboxyfluorescein from liposomes was markedly retarded by the presence of alpha-tocopherol in the bilayer of liposomal phospholipid membrane relative to cholesterol-containing liposomes and pure phospholipid liposomes. alpha-tocopherol-containing liposomes prolonged the oxidation of liposomes-embedded heme as an oxygen carrier. The oxidation index of alpha-tocopherol-containing liposomes was lower than those of cholesterol-containing liposomes and pure phospholipid liposomes. Thus alpha-tocopherol-containing liposomes may be useful for the carrier systems of nutrients and drugs to phospholipid bilayer and stabilized liposomes.
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KEYWORD
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